当嵌合体胚胎遇到灵长类动物时，问题则变得更复杂——由于亲缘关系更近，人猴胚胎的嵌合更有可能成功；但也由于亲缘关系更近，灵长类动物可能具有更高级的智慧和情绪，涉及它们的实验伦理总是要顾及更多。
现在，人猴嵌合体胚胎真的出现了。之前，伦理要求或许只为嵌合体胚胎划了一条模糊的边线；
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