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然而，制造“半人半动物”的胚胎，看起来仍是极大的伦理挑战。为了规范这类实验，不少国家制定了相应的规范，但目前各国的规范各不相同。
按照美国国立卫生研究院（NIH）的规定，有关人-灵长类动物嵌合体胚胎的实验无法得到他们的资金支持；2015 年，他们又宣布暂停资助人-非灵长类动物嵌合体胚
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